HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 22282481, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Cyanobenzoyl chloride | HCID 308483 | — |
| Reactant | Methyl isocyanoacetate | HCID 547815 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22282481 | HCID 22282481 | 50% |
Reaction Steps
The title compound was prepared in 50% yield by the condensation of 3-cyanobenzoyl chloride, methyl-isocyanoacetate and triethylamine in anhydrous THF following the general method of Suzuki et. al. Syn. Comm. 1972, 2, 237. 1H NMR (CDCl3) δ: 8.42-8.40 (d, 1H), 7.99 (s, 1H), 9.77-7.75 (d, 1H), 7.63 (t, 1H), 3.99 (s, 3H) ppm; Ammonia mass spectrum analysis m/z (rel intensity) 246(M+NH4+, 100), 229(M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06962935B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-d64999b317d745bb8f009da4f4fdb4ea |
| Source note | uspto-grants-2005_11 |