HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromide ion → Ethyl 2-bromo-3-(3-cyanophenyl)-3-oxopropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromide ion | HCID 259 | — |
| Reactant | Ethyl 3-(3-cyanophenyl)-3-oxopropanoate | HCID 11622629 | — |
| Product | Ethyl 2-bromo-3-(3-cyanophenyl)-3-oxopropionate | HCID 22282470 | 48% |
Reaction Steps
According to the procedure of Example 7, Part C, ethyl 3-(3-cyanophenyl)-3-oxopropionate (3.2 g, 14.7 mmol) was converted into the crude bromide, which was purified by flash chromatography (elution with 4:1 hexanes/ethyl acetate) to afford 2.1 g (48%) of the title compound. MS(H2O, GC/MS) 296/298 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06962935B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-3b481f92397f444283adbf7604800d7a |
| Source note | uspto-grants-2005_11 |