1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, methyl ester → 1H-Pyrrolo[3,2-b]pyridine-2-carbaldehyde

HRID 1062699Notes

Reaction equation

HRID 1062699 reaction equation
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10](OC)=[O:11]>[O-2].[Mn+2]>[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH:10]=[O:11]

Participants

3

Reactant 1

HCID 222817761H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, methyl ester

Product 1

HCID 222817391H-Pyrrolo[3,2-b]pyridine-2-carbaldehyde

Reagents, catalysts & solvents 1

HCID 160959Manganese oxideCatalyst

Procedure

This was prepared from methyl 1H-pyrrolo[3,2-b]pyridin-2-carboxylate (0.1 g) and amine (1d) by the method of Example 16c, (except that the alcohol was stirred with manganese (II) oxide overnight) and used without purification.

Workup

  1. customused without purification

Sources & evidence

ORD record
ord-4f1d990a173f4523b09763a9a1a3854c
Source dataset
uspto-grants-2005_11
Patent number
US06962917B2

Reaction notes

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