HCID 131725208, compound → HCID 69139506, compound

Participants

Reaction Steps

A solution of 100 mg (0.149 mmol) of the compound of example 9 in 6N hydrochloric acid and THF was heated at 60° C. for 4 h. The THF was removed in vacuo and the residue was freeze-dried. Following purification by means of preparative HPLC, chromatography over silica gel using dichloromethane/methanol/acetic acid/water (9.5/0.5/0.05/0.05), concentrating the product fractions and freeze-drying in the presence of 2N hydrochloric acid, 20 mg (21%) of the title compound were obtained.

Provenance & Evidence