Sodium Hydroxide → HCID 22281957, compound

Participants

Reaction Steps

4-(tert-butyl)-N-{[4-(tert-butyl)phenyl]sulfonyl}-N-[3-(2-methoxyethoxy)-1-methyl-4-(4-methylphenyl)-1H-pyrazol-5-yl]benzenesulfonamide (278 mg) (Preparation 36) was dissolved in dioxane, 1M sodium hydroxide solution (4 ml) was added and the reaction was stirred at reflux for 0.5 hours. The solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate (25 ml) and 1M hydrochloric acid (25 ml). The organic phase was separated, dried over magnesium sulphate and thesolvent removed under reduced pressure. The product was purified on silica (10 g) eluting with a solvent gradient of pentane:ethyl acectate (1:0 to 6.4) to yield the title compound as a white solid (160 mg).

Provenance & Evidence