HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1062829Generated: October 29, 2026
2-Nitrophenol → 1-(2-chloroethoxy)-2-nitrobenzene
https://huagongshe.com/reaction/1062829
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Nitrophenol | HCID 6947 | — |
| Reactant | 1-Bromo-2-Chloroethane | HCID 7849 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-chloroethoxy)-2-nitrobenzene | HCID 4362487 | — |
Reaction Steps
A suspension of 2-nitrophenol 101 (50.0 g, 0.36 mol), 1-bromo-2-chloroethane (45 mL, 0.54 mol), and K2CO3 (100.0 g, 0.72 mol) in DMF (200 mL) was stirred at 90° C. for 2 h, cooled to room temperature, poured into ice-water, filtered, washed with H2O and dried to give Compound 102, 70.3 g (96%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06962992B2 |
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| Source dataset | uspto-grants-2005_11 |
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| ORD ID | ord-de85966895ae4b91ae8f08cbb8d5a990 |
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| Source note | uspto-grants-2005_11 |
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