HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine chloride → 5-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-iodo-benzothiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine chloride | HCID 24640 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | (4-Methoxy-benzothiazol-2-yl)-carbamic acid methyl ester | HCID 21303403 | — |
| Reactant | 5-Methyl-thiophene-2-carboxylic acid (4-methoxy-benzothiazol-2-yl)-amide | HCID 36001214 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-iodo-benzothiazol-2-yl)-amide | HCID 86584906 | 93% |
Reaction Steps
Iodination of 5-methyl-thiophene-2-carboxylic acid (4-methoxy-benzothiazol-2-yl)-amide (5.17 g, 17 mmol) with iodine monochloride (2.26 ml, 44 mmol), sodium acetate (3.63 g, 44 mmol) and acetic acid (200 ml) in the same manner as described for (4-methoxy-benzothiazol-2-yl)-carbamic acid methyl ester affords the product as off-white solid in 93% yield. MS: m/e=430 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06963000B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-9c0ac871a8464558be98b32d0739b430 |
| Source note | uspto-grants-2005_11 |