(2-Methoxyethyl)(methyl)amine → HCID 10116133, compound

HRID 1062997Notes

Reaction equation

HRID 1062997 reaction equation
Cl[CH2:2][C:3]1[CH:28]=[CH:27][C:6]([C:7]([NH:9][C:10]2[S:11][C:12]3[C:18]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[CH:17][CH:16]=[C:15]([O:25][CH3:26])[C:13]=3[N:14]=2)=[O:8])=[CH:5][CH:4]=1.[CH3:29][O:30][CH2:31][CH2:32][NH:33][CH3:34]>>[CH3:29][O:30][CH2:31][CH2:32][N:33]([CH2:2][C:3]1[CH:28]=[CH:27][C:6]([C:7]([NH:9][C:10]2[S:11][C:12]3[C:18]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[CH:17][CH:16]=[C:15]([O:25][CH3:26])[C:13]=3[N:14]=2)=[O:8])=[CH:5][CH:4]=1)[CH3:34]

Participants

3

Reactant 2

HCID 300977(2-Methoxyethyl)(methyl)amineHCID 22283106HCID 22283106, compound

Product 1

HCID 10116133HCID 10116133, compoundYield 55%

Procedure

Conversion of 4-cloromethyl-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide (84 mg, 0.20 mmol) with N-(2-methoxyethyl)-methylamin (178 mg, 2.0 mmol) using the general procedure C affords the product as white solid in 55% yield.

Sources & evidence

ORD record
ord-8645cf02bb8a468d8fd42b9a1a815374
Source dataset
uspto-grants-2005_11
Patent number
US06963000B2

Reaction notes

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