HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → Thiomorpholine-4-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine | HCID 11402861 | — |
| Product | Thiomorpholine-4-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide | HCID 86584922 | 73% |
Reaction Steps
Conversion of 2-amino-4-methoxy-7-morpholin-4-yl-benzothiazol (100 mg, 0.377 mg) with phosgene (20% in toluene, 0.2 ml) and thiomorpholine (0.045 ml, 0.47 mmol) using the general procedure D affords the product as white solid in 73% yield. MS: m/e=395 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06963000B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-8452414f56c04689b46350ef43801816 |
| Source note | uspto-grants-2005_11 |