Water → HCID 22283025, compound

HRID 1063014Notes

Reaction equation

HRID 1063014 reaction equation
COC(=O)[NH:4][C:5]1[S:6][C:7]2[C:13]([CH:14]=[CH2:15])=[CH:12][CH:11]=[C:10]([O:16][CH3:17])[C:8]=2[N:9]=1.O>C(O)CO>[CH3:17][O:16][C:10]1[C:8]2[N:9]=[C:5]([NH2:4])[S:6][C:7]=2[C:13]([CH:14]=[CH2:15])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 962WaterHCID 86596309HCID 86596309, compound

Product 1

HCID 22283025HCID 22283025, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Conditions

Temperature
100 °C

Procedure

(4-Methoxy-7-vinyl-benzothiazol-2-yl)-carbamic acid methyl ester was dissolved in ethylenglycol/2N KOH (2:1) and stirred at 100° C. for 3 hrs. Then water was added and the mixture was extracted with CH2Cl2, the organic phase was washed with brine and dried over MgSO4. After evaporation the residue was crystallized from CH2Cl2. White crystals (64%); F.p.: 155-159° C.

Workup

  1. extractionthe mixture was extracted with CH2Cl2
  2. washthe organic phase was washed with brine
  3. dry with materialdried over MgSO4
  4. customAfter evaporation the residue
  5. customwas crystallized from CH2Cl2
  6. custom155-159° C.

Sources & evidence

ORD record
ord-bfc4824311994944b8f98702d15d8f98
Source dataset
uspto-grants-2005_11
Patent number
US06963000B2

Reaction notes

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