Picolyl chloride hydrochloride → 2-Dimethylaminopyridine

HRID 1063077Notes

Reaction equation

HRID 1063077 reaction equation
Cl.ClC[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1.[CH3:10][NH2:11].[CH3:12]CO>>[CH3:10][N:11]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)[CH3:12]

Participants

3

Reactant 2

HCID 23392Picolyl chloride hydrochlorideHCID 22028356Methylamine ethanol

Product 1

HCID 218852-DimethylaminopyridineYield 20%

Procedure

Using 2-chloromethyl-pyridine hydrochloride salt and 33% methylamine/EtOH the title compound was obtained as a colourless liquid (0.1 mm Hg, 47-48° C.) (20% yield), MS: m/e=93.1 (M-NHCH3).

Sources & evidence

ORD record
ord-6ea69d5ccbda4af49963b469b2cb2803
Source dataset
uspto-grants-2005_11
Patent number
US06963000B2

Reaction notes

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