Sodium Methoxide → (5-Methoxy-biphenyl-3-yl)-thiourea

HRID 1063079Notes

Reaction equation

HRID 1063079 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[CH:14]=[C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)=[S:11])(=O)C1C=CC=CC=1.C[O-].[Na+]>CO>[CH3:20][O:19][C:17]1[CH:18]=[C:13]([NH:12][C:10]([NH2:9])=[S:11])[CH:14]=[C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:16]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 222833191-Benzoyl-3-(5-methoxy-biphenyl-3-yl)-thiourea

Product 1

HCID 22283392(5-Methoxy-biphenyl-3-yl)-thioureaYield 88%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Benzoyl-3-(5-methoxy-biphenyl-3-yl)-thiourea (183 mg, 0.51 mmol) in methanol (5 ml) are treated with sodium methoxide (5.4M in methanol, 0.14 ml) and the formed precipitate is filtered off. Washing with methanol yields the product (115 mg, 88%) as off-white powder. MS: m/e=258 (M+).

Workup

  1. filtrationthe formed precipitate is filtered off
  2. washWashing with methanol

Sources & evidence

ORD record
ord-3cb3e3e8993b405cb766efd9bc3eb21a
Source dataset
uspto-grants-2005_11
Patent number
US06963000B2

Reaction notes

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