Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,4-Heptanedione, 6-methyl- | HCID 76354 | — |
| Reactant | 2-Cyanoethanethioamide | HCID 1416277 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178425008 | HCID 178425008 | 61.7% |
Reaction Steps
To a stirred solution of cyanothioacetamide (2.20 g, 22 mmol) and 6-methyl-2,4-heptanedione (3.12 g, 22 mmol) in anhydrous EtOH (40 mL) was added triethylamine (0.4 mL) and the reaction was heated at 50° C. for 1 h before it was allowed to cool to room temperature. Filtration and washing of the precipitates with EtOH gave 6-isobutyl-2-mercapto-4-methylnicotinonitrile as a yellow solid (2.8 g, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06964956B2 |
|---|
| Source dataset | uspto-grants-2005_11 |
|---|
| ORD ID | ord-e596cdfa137c4fe3821a20fb1f6b005e |
|---|
| Source note | uspto-grants-2005_11 |
|---|
