5-Amino-2-methylindole → HCID 91407794, compound

HRID 1063145Notes

Reaction equation

HRID 1063145 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][NH:19][C:20]([C:22]1[S:30][C:29]2[C:24](=[N:25][CH:26]=[CH:27][C:28]=2Cl)[CH:23]=1)=[O:21]>>[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][NH:19][C:20]([C:22]1[S:30][C:29]2[C:24](=[N:25][CH:26]=[CH:27][C:28]=2[NH:11][C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2]([CH3:1])=[CH:10]3)[CH:23]=1)=[O:21]

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 85797591HCID 85797591, compound

Product 1

HCID 91407794HCID 91407794, compound

Procedure

The title compound was prepared from 2-methyl-1H-indol-5-ylamine and 7-chloro-thieno[3,2-b]pyridine-2-carboxylic acid (pyridin-2-ylmethyl)-amide by a procedure analogous to Example 1C. MS: 414 (MH+); HPLC Rf: 4.34 min.; HPLC purity: 97%.

Sources & evidence

ORD record
ord-20143256c2a2496f9b44c9c1b5623847
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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