5-Amino-2-methylindole → HCID 90731278, compound

HRID 1063147Notes

Reaction equation

HRID 1063147 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.[CH3:12][N:13]([CH3:29])[CH2:14][CH2:15][NH:16][C:17]([C:19]1[S:27][C:26]2[C:21](=[N:22][CH:23]=[CH:24][C:25]=2Cl)[CH:20]=1)=[O:18]>>[CH3:12][N:13]([CH3:29])[CH2:14][CH2:15][NH:16][C:17]([C:19]1[S:27][C:26]2[C:21](=[N:22][CH:23]=[CH:24][C:25]=2[NH:11][C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2]([CH3:1])=[CH:10]3)[CH:20]=1)=[O:18]

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 91072374HCID 91072374, compound

Product 1

HCID 90731278HCID 90731278, compound

Procedure

The title compound was prepared from 2-methyl-1H-indol-5-ylamine and 7-chloro-thieno[3,2-b]pyridine-2-carboxylic acid (2-dimethylamino-ethyl)-amide by a procedure analogous to Example 1C. MS: 394 (MH+), HPLC Rf: 3.43; HPLC purity: 98%.

Sources & evidence

ORD record
ord-e5a5a4bcfe0741ac892757119c4cd475
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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