5-Amino-2-methylindole → HCID 91080984, compound

HRID 1063149Notes

Reaction equation

HRID 1063149 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][NH:22][C:23]([C:25]2[S:33][C:32]3[C:27](=[N:28][CH:29]=[CH:30][C:31]=3Cl)[CH:26]=2)=[O:24])[CH2:15][CH2:14]1>>[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][NH:22][C:23]([C:25]2[S:33][C:32]3[C:27](=[N:28][CH:29]=[CH:30][C:31]=3[NH:11][C:7]3[CH:8]=[C:9]4[C:4](=[CH:5][CH:6]=3)[NH:3][C:2]([CH3:1])=[CH:10]4)[CH:26]=2)=[O:24])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 91335553HCID 91335553, compound

Product 1

HCID 91080984HCID 91080984, compound

Procedure

The title compound was prepared from 2-methyl-1H-indol-5-ylamine and 7-chloro-thieno[3,2-b]pyridine-2-carboxylic acid [3-(4-methyl-piperazin-1-yl)-propyl]-amide by a procedure analogous to Example 1C. MS: 463 (MH+), HPLC Rf: 3.41 min.; HPLC purity: 99%.

Sources & evidence

ORD record
ord-aea1814184264f7dadc055619acbeea8
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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