5-Amino-2-methylindole → HCID 91246821, compound

HRID 1063153Notes

Reaction equation

HRID 1063153 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.[N:12]1[CH:17]=[CH:16][C:15]([CH2:18][NH:19][C:20]([C:22]2[S:30][C:29]3[C:24](=[N:25][CH:26]=[CH:27][C:28]=3Cl)[CH:23]=2)=[O:21])=[CH:14][CH:13]=1>>[N:12]1[CH:17]=[CH:16][C:15]([CH2:18][NH:19][C:20]([C:22]2[S:30][C:29]3[C:24](=[N:25][CH:26]=[CH:27][C:28]=3[NH:11][C:7]3[CH:8]=[C:9]4[C:4](=[CH:5][CH:6]=3)[NH:3][C:2]([CH3:1])=[CH:10]4)[CH:23]=2)=[O:21])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 85797600HCID 85797600, compound

Product 1

HCID 91246821HCID 91246821, compound

Procedure

The title compound was prepared from 2-methyl-1H-indol-5-ylamine and 7-chloro-thieno[3,2-b]pyridine-2-carboxylic acid (pyridin-4-ylmethyl)-amide by a procedure analogous to Example 1C. MS: 414 (MH+), HPLC Rf: 3.97 min.; HPLC purity 94%.

Sources & evidence

ORD record
ord-2699433365da41ed92b418a764a11a7b
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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