5-Amino-2-methylindole → HCID 91013198, compound

HRID 1063159Notes

Reaction equation

HRID 1063159 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.[N:12]1([CH2:18][CH2:19][NH:20][C:21]([C:23]2[S:31][C:30]3[C:25](=[N:26][CH:27]=[CH:28][C:29]=3Cl)[CH:24]=2)=[O:22])[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[N:12]1([CH2:18][CH2:19][NH:20][C:21]([C:23]2[S:31][C:30]3[C:25](=[N:26][CH:27]=[CH:28][C:29]=3[NH:11][C:7]3[CH:8]=[C:9]4[C:4](=[CH:5][CH:6]=3)[NH:3][C:2]([CH3:1])=[CH:10]4)[CH:24]=2)=[O:22])[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 90906051HCID 90906051, compound

Product 1

HCID 91013198HCID 91013198, compound

Procedure

The title compound was prepared from 2-methyl-1H-indol-5-ylamine and 7-chloro-thieno[3,2-b]pyridine-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide by a procedure analogous to Example 1C. MS: 436 (MH+); HPLC Rf: 3.45 min.; HPLC purity 94%.

Sources & evidence

ORD record
ord-85fde7175d4748a7ac6f963a493ad8cd
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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