Morpholine → 7-Chloro-thieno[3,2-b]pyridin-2-yl-morpholin-4-yl-methanone

HRID 1063168Notes

Reaction equation

HRID 1063168 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]2[CH:14]=[C:15]([C:17]([O-])=[O:18])[S:16][C:9]=12.[Li+]>>[Cl:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]2[CH:14]=[C:15]([C:17]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:18])[S:16][C:9]=12

Participants

3

Reactant 2

HCID 8083MorpholineHCID 23677819Lithium 7-chlorothieno[3,2-b]pyridine-2-carboxylate

Product 1

HCID 222786227-Chloro-thieno[3,2-b]pyridin-2-yl-morpholin-4-yl-methanone

Procedure

The title compound was prepared from morpholine and lithium 7-chloro-thieno[3,2-b]pyridine-2-carboxylate by a procedure analogous to Example 1B. MS: 282/284 (MH+), HPLC Rf: 3.96 min.; HPLC purity 98%.

Sources & evidence

ORD record
ord-72858a0370354616ad8ed2949fc80d67
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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