5-Amino-2-methylindole → HCID 10116300, compound

HRID 1063180Notes

Reaction equation

HRID 1063180 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:17][CH2:16][CH:15]([NH:18][C:19]([CH:21]4[CH2:24][CH2:23][CH2:22]4)=[O:20])[CH2:14]3)=[O:12])[S:10][C:3]=12.[CH3:25][C:26]1[NH:27][C:28]2[C:33]([CH:34]=1)=[CH:32][C:31]([NH2:35])=[CH:30][CH:29]=2>>[CH3:25][C:26]1[NH:27][C:28]2[C:33]([CH:34]=1)=[CH:32][C:31]([NH:35][C:2]1[CH:7]=[CH:6][N:5]=[C:4]3[CH:8]=[C:9]([C:11]([N:13]4[CH2:17][CH2:16][CH:15]([NH:18][C:19]([CH:21]5[CH2:24][CH2:23][CH2:22]5)=[O:20])[CH2:14]4)=[O:12])[S:10][C:3]=13)=[CH:30][CH:29]=2

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 91195843HCID 91195843, compound

Product 1

HCID 10116300HCID 10116300, compound

Procedure

The title compound was prepared from (+/−)-cyclobutanecarboxylic acid {1-[7-chloro-thieno[3,2-b]pyridine-2-carbonyl]-pyrrolidin-3-yl}-amide and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C. MS: 474 (MH+); HPLC Rf: 4.37 min.; HPLC purity 97%.

Sources & evidence

ORD record
ord-23abc7fdb7004c0faf9245d9ed4de9f6
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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