5-Amino-2-methylindole → HCID 10179516, compound

HRID 1063188Notes

Reaction equation

HRID 1063188 reaction equation
[CH3:1][O:2][CH:3]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[S:18][C:17]3[C:12](=[N:13][CH:14]=[CH:15][C:16]=3Cl)[CH:11]=2)=[O:9])[CH2:4]1.[CH3:20][C:21]1[NH:22][C:23]2[C:28]([CH:29]=1)=[CH:27][C:26]([NH2:30])=[CH:25][CH:24]=2>>[CH3:1][O:2][CH:3]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[S:18][C:17]3[C:12](=[N:13][CH:14]=[CH:15][C:16]=3[NH:30][C:26]3[CH:27]=[C:28]4[C:23](=[CH:24][CH:25]=3)[NH:22][C:21]([CH3:20])=[CH:29]4)[CH:11]=2)=[O:9])[CH2:4]1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 22143527(3-Methoxy-pyrrolidin-1-yl)-[7-chloro-thieno[3,2-b]pyridin-2-yl]-methanone

Product 1

HCID 10179516HCID 10179516, compound

Procedure

The title compound was prepared from (3-methoxy-pyrrolidin-1-yl)-[7-chloro-thieno[3,2-b]pyridin-2-yl]-methanone and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C. MS: 407 (MH+); HPLC Rf: 4.22 min.; HPLC purity 96%.

Sources & evidence

ORD record
ord-8ec6d71f8e35418fad64fc09eda50131
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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