tert-butyl N-(pyrrolidin-3-yl)carbamate → HCID 69737603, compound

HRID 1063189Notes

Reaction equation

HRID 1063189 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([O-:13])=O)[S:10][C:3]=12.[Li+].[C:15]([O:19][C:20](=[O:27])[NH:21][CH:22]1[CH2:26][CH2:25][NH:24][CH2:23]1)([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20](=[O:27])[NH:21][CH:22]1[CH2:26][CH2:25][N:24]([C:11]([C:9]2[S:10][C:3]3[C:4](=[N:5][CH:6]=[CH:7][C:2]=3[Cl:1])[CH:8]=2)=[O:13])[CH2:23]1)([CH3:18])([CH3:16])[CH3:17]

Participants

3

Reactant 2

HCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 23677819Lithium 7-chlorothieno[3,2-b]pyridine-2-carboxylate

Product 1

HCID 69737603HCID 69737603, compound

Procedure

The title compound was prepared from lithium 7-chloro-thieno[3,2-b]pyridine-2-carboxylate and (+/−)-pyrrolidin-3-yl-carbamic acid tert butyl ester by a method analogous to Example 1B. MS: 382/384 (MH+); HPLC Rf: 5.21 min.; HPLC purity 99%.

Sources & evidence

ORD record
ord-ca9f19382d8a4716a811224663c17992
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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