5-Amino-2-methylindole → HCID 69957685, compound

HRID 1063190Notes

Reaction equation

HRID 1063190 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]1[CH2:12][CH2:11][N:10]([C:13]([C:15]2[S:23][C:22]3[C:17](=[N:18][CH:19]=[CH:20][C:21]=3Cl)[CH:16]=2)=[O:14])[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[CH3:26][C:27]1[NH:28][C:29]2[C:34]([CH:35]=1)=[CH:33][C:32]([NH2:36])=[CH:31][CH:30]=2>>[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]1[CH2:12][CH2:11][N:10]([C:13]([C:15]2[S:23][C:22]3[C:17](=[N:18][CH:19]=[CH:20][C:21]=3[NH:36][C:32]3[CH:33]=[C:34]4[C:29](=[CH:30][CH:31]=3)[NH:28][C:27]([CH3:26])=[CH:35]4)[CH:16]=2)=[O:14])[CH2:9]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 69737603HCID 69737603, compound

Product 1

HCID 69957685HCID 69957685, compound

Procedure

The title compound was prepared from (+/−)-[1-(7-chloro-thieno[3,2-b]pyridine-2-carbonyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C. MS: 492 (MH+); HPLC Rf: 5.23 min.; HPLC purity 96%.

Sources & evidence

ORD record
ord-015564c0463a4b4b90f4ed4d47080993
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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