Dimethylsulphamoyl chloride → HCID 91253224, compound

HRID 1063191Notes

Reaction equation

HRID 1063191 reaction equation
[CH3:1][N:2]([CH3:7])[S:3](Cl)(=[O:5])=[O:4].[NH2:8][CH:9]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[S:24][C:23]3[C:18](=[N:19][CH:20]=[CH:21][C:22]=3[Cl:25])[CH:17]=2)=[O:15])[CH2:10]1>>[Cl:25][C:22]1[CH:21]=[CH:20][N:19]=[C:18]2[CH:17]=[C:16]([C:14]([N:11]3[CH2:12][CH2:13][CH:9]([NH:8][S:3](=[O:5])(=[O:4])[N:2]([CH3:7])[CH3:1])[CH2:10]3)=[O:15])[S:24][C:23]=12

Participants

3

Reactant 2

HCID 83372Dimethylsulphamoyl chlorideHCID 22278662HCID 22278662, compound

Product 1

HCID 91253224HCID 91253224, compound

Procedure

The title compound was prepared from dimethylsulfamoyl chloride and (3-amino-pyrrolidin-1-yl)-(7-chloro-thieno[3,2-b]pyridin-2yl)-methanone by a procedure analogous to Example 64C. MS: 389/391 (MH+); HPLC Rf: 4.26 min.; HPLC purity 99%.

Sources & evidence

ORD record
ord-d3428e0fcac0471a9f5095ec6e553dd6
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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