5-Amino-2-methylindole → HCID 91064034, compound

HRID 1063196Notes

Reaction equation

HRID 1063196 reaction equation
[CH3:1][N:2]([CH:9]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[S:24][C:23]3[C:18](=[N:19][CH:20]=[CH:21][C:22]=3Cl)[CH:17]=2)=[O:15])[CH2:10]1)[C:3]([CH:5]1[CH2:8][CH2:7][CH2:6]1)=[O:4].[CH3:26][C:27]1[NH:28][C:29]2[C:34]([CH:35]=1)=[CH:33][C:32]([NH2:36])=[CH:31][CH:30]=2>>[CH3:1][N:2]([CH:9]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[S:24][C:23]3[C:18](=[N:19][CH:20]=[CH:21][C:22]=3[NH:36][C:32]3[CH:33]=[C:34]4[C:29](=[CH:30][CH:31]=3)[NH:28][C:27]([CH3:26])=[CH:35]4)[CH:17]=2)=[O:15])[CH2:10]1)[C:3]([CH:5]1[CH2:8][CH2:7][CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 91486271HCID 91486271, compound

Product 1

HCID 91064034HCID 91064034, compound

Procedure

The title compound was prepared from (+/−)-cyclobutane carboxylic acid methyl-{1-[7-chloro-thieno[3,2-b]pyridine-2-carbonyl]-pyrrolidin-3-yl}-amide and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C. MS: 488 (MH+); HPLC Rf: 4.84 min.; HPLC purity 95%.

Sources & evidence

ORD record
ord-a67b5f569deb45e3ac089dd5029438f3
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

Loading…