5-Amino-2-methylindole → HCID 90900078, compound

HRID 1063198Notes

Reaction equation

HRID 1063198 reaction equation
[CH3:1][N:2]([CH:9]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[S:24][C:23]3[C:18](=[N:19][CH:20]=[CH:21][C:22]=3Cl)[CH:17]=2)=[O:15])[CH2:10]1)[S:3](=[O:8])(=[O:7])[N:4]([CH3:6])[CH3:5].[CH3:26][C:27]1[NH:28][C:29]2[C:34]([CH:35]=1)=[CH:33][C:32]([NH2:36])=[CH:31][CH:30]=2>>[CH3:1][N:2]([CH:9]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[S:24][C:23]3[C:18](=[N:19][CH:20]=[CH:21][C:22]=3[NH:36][C:32]3[CH:33]=[C:34]4[C:29](=[CH:30][CH:31]=3)[NH:28][C:27]([CH3:26])=[CH:35]4)[CH:17]=2)=[O:15])[CH2:10]1)[S:3](=[O:8])(=[O:7])[N:4]([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 91272593HCID 91272593, compound

Product 1

HCID 90900078HCID 90900078, compound

Procedure

The title compound was prepared from (+/−)-dimethylsulfamic acid methyl-{1-[7-chloro-thieno[3,2-b]pyridine-2-carbonyl]-pyrrolidin-3-yl}-amide and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C. MS: 513 (MH+); HPLC Rf: 4.76 min.; HPLC purity 92%.

Sources & evidence

ORD record
ord-317cc5f09c3847cf96c86ab7ac382150
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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