5-Amino-2-methylindole → HCID 91261659, compound

HRID 1063200Notes

Reaction equation

HRID 1063200 reaction equation
[CH3:1][N:2]([CH:7]1[CH2:11][CH2:10][N:9]([C:12]([C:14]2[S:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][C:20]=3Cl)[CH:15]=2)=[O:13])[CH2:8]1)[S:3]([CH3:6])(=[O:5])=[O:4].[CH3:24][C:25]1[NH:26][C:27]2[C:32]([CH:33]=1)=[CH:31][C:30]([NH2:34])=[CH:29][CH:28]=2>>[CH3:1][N:2]([CH:7]1[CH2:11][CH2:10][N:9]([C:12]([C:14]2[S:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][C:20]=3[NH:34][C:30]3[CH:31]=[C:32]4[C:27](=[CH:28][CH:29]=3)[NH:26][C:25]([CH3:24])=[CH:33]4)[CH:15]=2)=[O:13])[CH2:8]1)[S:3]([CH3:6])(=[O:5])=[O:4]

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 91069034HCID 91069034, compound

Product 1

HCID 91261659HCID 91261659, compound

Procedure

The title compound was prepared from (+/−)-methanesulfonic acid methyl-{1-[7-chloro-thieno[3,2-b]pyridine-2-carbonyl]-pyrrolidin-3-yl}-amide and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C. MS: 484 (MH+); HPLC Rf: 3.69 min.; HPLC purity 91%.

Sources & evidence

ORD record
ord-290c4efa0a1a41e98165e9112540601c
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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