5-Amino-2-methylindole → HCID 69736406, compound

HRID 1063206Notes

Reaction equation

HRID 1063206 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:17][CH2:16][C@H:15]([O:18][CH2:19][CH:20]4[CH2:22][CH2:21]4)[CH2:14]3)=[O:12])[S:10][C:3]=12.[CH3:23][C:24]1[NH:25][C:26]2[C:31]([CH:32]=1)=[CH:30][C:29]([NH2:33])=[CH:28][CH:27]=2>>[CH:20]1([CH2:19][O:18][C@H:15]2[CH2:16][CH2:17][N:13]([C:11]([C:9]3[S:10][C:3]4[C:4](=[N:5][CH:6]=[CH:7][C:2]=4[NH:33][C:29]4[CH:30]=[C:31]5[C:26](=[CH:27][CH:28]=4)[NH:25][C:24]([CH3:23])=[CH:32]5)[CH:8]=3)=[O:12])[CH2:14]2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 69736387HCID 69736387, compound

Product 1

HCID 69736406HCID 69736406, compound

Procedure

The title compound was prepared from (3S)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(3-cyclopropylmethoxy-pyrrolidin-1-yl)-methanone and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C. MS: 447.2 (MH+); HPLC Rf: 5.341 min.; HPLC purity: 100%.

Sources & evidence

ORD record
ord-5e7403257fb64ad482fb91f7a2e935d2
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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