5-Amino-2-methylindole → HCID 23401155, compound

HRID 1063208Notes

Reaction equation

HRID 1063208 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:17][CH2:16][C@@H:15]([O:18][CH2:19][CH2:20][O:21][CH3:22])[CH2:14]3)=[O:12])[S:10][C:3]=12.[CH3:23][C:24]1[NH:25][C:26]2[C:31]([CH:32]=1)=[CH:30][C:29]([NH2:33])=[CH:28][CH:27]=2>>[CH3:22][O:21][CH2:20][CH2:19][O:18][C@@H:15]1[CH2:16][CH2:17][N:13]([C:11]([C:9]2[S:10][C:3]3[C:4](=[N:5][CH:6]=[CH:7][C:2]=3[NH:33][C:29]3[CH:30]=[C:31]4[C:26](=[CH:27][CH:28]=3)[NH:25][C:24]([CH3:23])=[CH:32]4)[CH:8]=2)=[O:12])[CH2:14]1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 23401162HCID 23401162, compound

Product 1

HCID 23401155HCID 23401155, compound

Procedure

The title compound was prepared from (3R)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-[3-(2-methoxy-ethoxy)-pyrrolidin-1-yl]-methanone and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C. MS: 451.3 (MH+); HPLC Rf: 4.385 min.; HPLC purity: 97%.

Sources & evidence

ORD record
ord-107fae4bf29e41bca9d2b4526099faaa
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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