5-Amino-2-methylindole → HCID 23401167, compound

HRID 1063212Notes

Reaction equation

HRID 1063212 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:17][C@H:16]([O:18][CH3:19])[C@@H:15]([O:20][CH3:21])[CH2:14]3)=[O:12])[S:10][C:3]=12.[CH3:22][C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([NH2:32])=[CH:27][CH:26]=2>>[CH3:21][O:20][C@@H:15]1[C@@H:16]([O:18][CH3:19])[CH2:17][N:13]([C:11]([C:9]2[S:10][C:3]3[C:4](=[N:5][CH:6]=[CH:7][C:2]=3[NH:32][C:28]3[CH:29]=[C:30]4[C:25](=[CH:26][CH:27]=3)[NH:24][C:23]([CH3:22])=[CH:31]4)[CH:8]=2)=[O:12])[CH2:14]1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 20745990HCID 20745990, compound

Product 1

HCID 23401167HCID 23401167, compound

Procedure

The title compound was prepared from (3S,4S)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(3,4-dimethoxy-pyrrolidin-1-yl)-methanone and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C MS: 437.4 (MH+); HPLC Rf: 4.432 min.; HPLC purity: 98%.

Sources & evidence

ORD record
ord-b15ee84f1e9e4bc292c6992154548dbe
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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