(S)-4-(pyrrolidin-2-ylmethyl)morpholine → HCID 23401151, compound

HRID 1063220Notes

Reaction equation

HRID 1063220 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[CH2:6][N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1.[CH3:13][C:14]1[NH:15][C:16]2[C:21]([CH:22]=1)=[CH:20][C:19]([NH:23][C:24]1[CH:29]=[CH:28][N:27]=[C:26]3[CH:30]=[C:31]([C:33](O)=[O:34])[S:32][C:25]=13)=[CH:18][CH:17]=2>>[CH3:13][C:14]1[NH:15][C:16]2[C:21]([CH:22]=1)=[CH:20][C:19]([NH:23][C:24]1[CH:29]=[CH:28][N:27]=[C:26]3[CH:30]=[C:31]([C:33]([N:1]4[CH2:5][CH2:4][CH2:3][C@H:2]4[CH2:6][N:7]4[CH2:8][CH2:9][O:10][CH2:11][CH2:12]4)=[O:34])[S:32][C:25]=13)=[CH:18][CH:17]=2

Participants

3

Reactant 2

HCID 7141612(S)-4-(pyrrolidin-2-ylmethyl)morpholineHCID 22278637HCID 22278637, compound

Product 1

HCID 23401151HCID 23401151, compound

Procedure

The title compound was prepared from (S)-4-pyrrolidin-2-ylmethyl-morpholine and 7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridine-2-carboxylic acid by a procedure analogous to Example 21B. MS: 476.3 (MH+); HPLC Rf: 5.378 min.; HPLC purity: 92%.

Sources & evidence

ORD record
ord-607041c521fb476daf9c356e65edf0d5
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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