HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-dimethyl-1H-indol-5-amine → (3S)-[7-(2,3-Dimethyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-(3-methoxy-pyrrolidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-dimethyl-1H-indol-5-amine | HCID 258688 | — |
| Reactant | (3S)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(3-methoxy-pyrrolidin-1-yl)-methanone | HCID 23401173 | — |
| Product | (3S)-[7-(2,3-Dimethyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-(3-methoxy-pyrrolidin-1-yl)-methanone | HCID 23401169 | — |
Reaction Steps
The title compound was prepared from (3S)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(3-methoxy-pyrrolidin-1-yl)-methanone and 2,3-dimethyl-1H-indol-5-ylamine by a procedure analogous to Example 99. MS: 421.2 (MH+); HPLC Rf: 4.80 min.; HPLC purity: 99%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964961B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-2d7afe59631d4ad681076f1fe8dd82dc |
| Source note | uspto-grants-2005_11 |