HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-chloro-2-methyl-1H-indol-5-amine → (3S)-[7-(3-Chloro-2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-(3-methoxy-pyrrolidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-chloro-2-methyl-1H-indol-5-amine | HCID 22278621 | — |
| Reactant | (3S)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(3-methoxy-pyrrolidin-1-yl)-methanone | HCID 23401173 | — |
| Product | (3S)-[7-(3-Chloro-2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-(3-methoxy-pyrrolidin-1-yl)-methanone | HCID 23401170 | — |
Reaction Steps
The title compound was prepared from (3S)-(7-chloro-thieno[3,2-b]pyridin-2-yl)-(3-methoxy-pyrrolidin-1-yl)-methanone and 3-chloro-2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 103. MS: 441.2/443.2; 407.2(MH+); HPLC Rf: 4.96 min.; HPLC purity: 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964961B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-c2b0437fa27a4dfb8a4a705ca23fddb0 |
| Source note | uspto-grants-2005_11 |