5-Amino-2-methylindole → HCID 22278642, compound

HRID 1063229Notes

Reaction equation

HRID 1063229 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]3)=[O:12])[S:10][C:3]=12.[CH3:22][C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([NH2:32])=[CH:27][CH:26]=2>>[CH3:22][C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([NH:32][C:2]1[CH:7]=[CH:6][N:5]=[C:4]3[CH:8]=[C:9]([C:11]([N:13]4[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]4)=[O:12])[S:10][C:3]=13)=[CH:27][CH:26]=2

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 22278634HCID 22278634, compound

Product 1

HCID 22278642HCID 22278642, compound

Procedure

The title compound was prepared from 1-[4-(7-chloro-thieno[3,2-b]pyridine-2-carbonyl)-piperazin-1-yl]-ethanone and 2-methyl-1H-indol-5-ylamine by a procedure analogous to Example 1C. MS: 434 (MH+); HPLC Rf: 3.52; HPLC purity: 99%.

Sources & evidence

ORD record
ord-845f55e386c64d6a968e23837f9c6236
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

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