HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Amino-1-(diphenylmethyl)azetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-(Diphenylmethyl)azetidin-3-yl methanesulfonate | HCID 2758716 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-1-(diphenylmethyl)azetidine | HCID 5744546 | — |
Reaction Steps
Ammonia gas was bubbled through a solution of methanesulfonic acid 1-benzhydryl-azetidin-3-yl ester (952.4 mg, 3 mmol) in MeOH (15 mL). After 2 hours, TLC showed the reaction to be complete. The title compound was obtained as a white solid (643.5 mg, 90%) after removal of the solvent. MS: 239 (MH+); HPLC Rf: 3.54 min; HPLC purity: 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964961B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-06da30a5bf93434caaa6db6e86543b2b |
| Source note | uspto-grants-2005_11 |