Acetyl chloride → N-[1-(Diphenylmethyl)-3-azetidinyl]acetamide

HRID 1063231Notes

Reaction equation

HRID 1063231 reaction equation
[CH:1]([N:14]1[CH2:17][CH:16]([NH2:18])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](Cl)(=[O:21])[CH3:20]>>[CH:1]([N:14]1[CH2:17][CH:16]([NH:18][C:19](=[O:21])[CH3:20])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 57445463-Amino-1-(diphenylmethyl)azetidine

Product 1

HCID 13495841N-[1-(Diphenylmethyl)-3-azetidinyl]acetamide

Procedure

The title compound was prepared from 1-benzhydryl-azetidin-3-ylamine and acetyl chloride by a procedure analogous to Example 70A. MS: 281 (MH+); HPLC Rf: 5.57 min; HPLC purity: 93%.

Sources & evidence

ORD record
ord-55a6dcc0299845e19693ba5993716908
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

Loading…