Acetyl chloride → HCID 69737431, compound

HRID 1063234Notes

Reaction equation

[CH3:1][O:2][CH2:3][C@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9]([C:11]1[S:19][C:18]2[C:13](=[N:14][CH:15]=[CH:16][C:17]=2[NH:20][C:21]2[CH:22]=[C:23]3[C:27](=[CH:28][CH:29]=2)[NH:26][C:25]([CH3:30])=[CH:24]3)[CH:12]=1)=[O:10].[C:31](Cl)(=[O:33])[CH3:32]>>[CH3:1][O:2][CH2:3][C@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9]([C:11]1[S:19][C:18]2[C:13](=[N:14][CH:15]=[CH:16][C:17]=2[NH:20][C:21]2[CH:22]=[C:23]3[C:27](=[CH:28][CH:29]=2)[N:26]([C:31](=[O:33])[CH3:32])[C:25]([CH3:30])=[CH:24]3)[CH:12]=1)=[O:10]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 10223914HCID 10223914, compound

Product 1

HCID 69737431HCID 69737431, compound

Procedure

The title compound was prepared by method analogous to Example 70A using (2R)-(2-methoxymethyl-pyrrolidin-1-yl)-[7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-methanone and acetyl chloride as starting materials. MS: 463 (MH+); HPLC Rf: 4.88 min; HPLC purity: 94%.

Sources & evidence

ORD record: ord-30b1e0e74e854f658e5a431c82b4adc6
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06964961B2

Reaction notes

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