HCID 12732175, compound → HCID 23401133, compound

HRID 1063236Notes

Reaction equation

HRID 1063236 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]3[CH:18]=[C:19]([C:21]([OH:23])=O)[S:20][C:13]=13)=[CH:6][CH:5]=2.[NH:24]1[CH2:28][CH2:27][CH2:26][C@@H:25]1[C:29]([OH:32])([CH3:31])[CH3:30]>>[OH:32][C:29]([C@H:25]1[CH2:26][CH2:27][CH2:28][N:24]1[C:21]([C:19]1[S:20][C:13]2[C:14](=[N:15][CH:16]=[CH:17][C:12]=2[NH:11][C:7]2[CH:6]=[C:5]3[C:4](=[CH:9][CH:8]=2)[NH:3][C:2]([CH3:10])=[CH:1]3)[CH:18]=1)=[O:23])([CH3:31])[CH3:30]

Participants

3

Reactant 2

HCID 12732175HCID 12732175, compoundHCID 22278637HCID 22278637, compound

Product 1

HCID 23401133HCID 23401133, compound

Procedure

The title compound was prepared from 7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridine-2-carboxylic acid and (R)-2-pyrrolidin-2-yl-propan-2-ol by a procedure analogous to Example 21B. MS: 435.2; HPLC Rf: 4.656 min.; HPLC purity: 97%.

Sources & evidence

ORD record
ord-237286cc020740278f67228f10636084
Source dataset
uspto-grants-2005_11
Patent number
US06964961B2

Reaction notes

Loading…