HCID 22278866, compound → 3-Ethylpiperidin-4-amine
Reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5](C(OCC)=O)[CH2:4][CH:3]1[CH2:13][CH3:14]>[OH-].[Na+]>[NH2:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH:3]1[CH2:13][CH3:14]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 120 °C
Procedure
4-Amino-1-carbethoxy-3-ethylpiperidine was suspended in 5 M NaOH solution (36 ml), stirred at 120° C. for 120 hr, cooled, extracted with ethyl acetate, dried (Na2SO4) and concentrated to dryness to afford 4-amino-3-ethylpiperidine. Yield 3.1 g (59.6%), C7H16N2, m/z 129 (M+1).
Workup
- temperaturecooled
- extractionextracted with ethyl acetate
- dry with materialdried (Na2SO4)
- concentrationconcentrated to dryness
Sources & evidence
- ORD record
- ord-c1cb56e5354f42409e54cc59addb8577
- Source dataset
- uspto-grants-2005_11
- Patent number
- US06964966B2
Reaction notes
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