HCID 22278836, compound → HCID 10171257, compound

Participants

Reaction Steps

A mixture of 20% Pd(OH)2 on carbon (0.4 g) and 1-benzyl-4-ethylamino-3,3-dimethylpiperidine (1.3 g, 5.3 mmol) in methanol (10 ml) was stirred in hydrogen atmosphere (1 atm.) at ambient temperature for 15 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford 4-ethylamino-3,3-dimethylpiperidine. Yield 0.8 g (97%), C9H20N2, m/z 157 (M+1), PMR (CDCl3): 0.9 (s, 3H), 1.06 (s, 3H), 1.18-1.38 (m, 5H), 1.85 (bs, 2H, D2O exchangeable), 1.64-2.8 (m, 6H), 2.94 (m, 1H).

Provenance & Evidence