Acetic Anhydride → HCID 22278911, compound

HRID 1063306Notes

Reaction equation

HRID 1063306 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:11][C:10]1([CH3:23])[CH3:22]>N1C=CC=CC=1>[C:5]([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:11][C:10]1([CH3:23])[CH3:22])(=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 102361061-Benzyl-3,3-diMethyl-piperidin-4-aMine

Product 1

HCID 22278911HCID 22278911, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Acetic anhydride (3 ml) was added to a stirred solution of 4-amino-1-benzyl-3,3-dimethylpiperidine (2.0 g, 9.17 mmol) in pyridine (5 ml) and stirred for 1 hr. The reaction mixture was concentrated to furnish 4-acetylamino-1-benzyl-3,3-dimethyl piperidine as an oil. Yield 1.8 g (76%), C16H24N2O, m/z 261 (M+1), PMR (CDCl3): 0.84 (s, 3H), 0.98 (s, 3H), 1.64 (m, 2H), 2.02 (s, 3H), 2.12 (m, 2H), 2.44 (d, 1H), 2.84 (d, 1H), 3.44 (d, 2H), 3.7 (m, 1H), 5.3 (bs, 1H), 7.31 (m, 5H).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-9f2a1dd014c2419aa2297a4cc5b41219
Source dataset
uspto-grants-2005_11
Patent number
US06964966B2

Reaction notes

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