HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Acetate → 3-Methyl-1-(phenylmethyl)-4-piperidinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 1-Benzyl-3-methyl-4-piperidone | HCID 560965 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Methyl-1-(phenylmethyl)-4-piperidinamine | HCID 22278835 | — |
Reaction Steps
Ammonium acetate (178.3 g, 2.31 mol) was charged to a solution of 1-benzyl-3-methyl-4-piperidone (47 g, 0.232 mol) in 500 ml methanol. The suspension was stirred for 4 hours at room temperature. Sodium cyanoborohydride (7.3 g, 0.16 mol) was added in lots at 10° C. and it was stirred for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964966B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-df41c35c708f477297c1c9586a13c77d |
| Source note | uspto-grants-2005_11 |