2-(Ethylamino)ethanol → HCID 10272105, compound

HRID 1063357Notes

Reaction equation

HRID 1063357 reaction equation
Cl.Br[CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22](Cl)=[O:23])=[CH:17][CH:16]=1.[CH2:25]([NH:27][CH2:28][CH2:29][OH:30])[CH3:26]>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22]([N:11]2[CH2:12][CH2:13][CH:8]([O:7][CH2:6][CH2:5][CH2:4][CH2:3][N:27]([CH2:25][CH3:26])[CH2:28][CH2:29][OH:30])[CH2:9][CH2:10]2)=[O:23])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 80722-(Ethylamino)ethanolHCID 906924-Chlorophenylacetyl chlorideHCID 85812949HCID 85812949, compound

Product 1

HCID 10272105HCID 10272105, compound

Procedure

In analogy to example 1.4 and 1.5, reaction of 4-(4-Brom-butoxy)-piperidine hydrogen chloride with (4-chloro-phenyl)-acetyl chloride and 2-ethylamino-ethanol yielded 2-(4-Chloro-phenyl)-1-(4-{4-[ethyl-(2-hydroxy-ethyl)-amino]-butoxy}-piperidin-1-yl)-ethanone, MS: 397 (MH+).

Sources & evidence

ORD record
ord-09149fd79f8649958108e19ca5083336
Source dataset
uspto-grants-2005_11
Patent number
US06964974B2

Reaction notes

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