HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-(6-Bromo-hexyloxy)-piperidine-1-sulfonic acid phenylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phenylsulfamoyl chloride | HCID 11564615 | — |
| Reactant | 4-(6-Bromo-hexyloxy)-piperidine hydrochloride | HCID 22279420 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(6-Bromo-hexyloxy)-piperidine-1-sulfonic acid phenylamide | HCID 69784539 | 135.2% |
Reaction Steps
A solution of 3 g (10 mmol) 4-(6-Bromo-hexyloxy)-piperidine hydrochloride and 3.44 g (18 mmol) of Phenylsulfamoyl chloride in 100 ml dry CH2Cl2 was treated with 6.95 ml (49.9 mmol) of triethylamine. The reaction was stirred for 4 h at RT, diluted with CH2Cl2 and washed with water. The organic phase was dried (MgSO4) and evaporated to yield 5.67 g (quantitative) of 4-(6-Bromo-hexyloxy)-piperidine-1-sulfonic acid phenylamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964974B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-4270c30b8777490aa456318db1470513 |
| Source note | uspto-grants-2005_11 |