Acetonitrile → HCID 55280058, compound

HRID 1063366Notes

Reaction equation

HRID 1063366 reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].[S:9]([Cl:13])(Cl)(=[O:11])=[O:10].[CH3:14]C#N>>[CH2:2]([O:4][C:5](=[O:8])[CH:6]([NH:7][S:9]([Cl:13])(=[O:11])=[O:10])[CH3:14])[CH3:3]

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 24648Sulfuryl chlorideHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 55280058HCID 55280058, compound

Conditions

Temperature
65 °C

Procedure

Glycine ethyl ester hydrochloride (1 eq.) was dissolved in CH3CN and placed in an ice bath. Sulfuryl chloride (3 eq.) was added slowly (20 min). The reaction mixture was stirred at room temperature for 15 min and at 65° C. for 20 h. The solvent was evaporated and the residue was dried under high vacuum to yield Chlorosulfonylamino-propionic acid ethyl ester. The crude sulfamoyl chloride was used in the next step without further purification.

Workup

  1. customplaced in an ice bath
  2. customThe solvent was evaporated
  3. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-11acc4933acc41d282ec441c94ce852e
Source dataset
uspto-grants-2005_11
Patent number
US06964974B2

Reaction notes

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