Methanol → HCID 69784770, compound

Participants

Reaction Steps

A solution of 320 mg (0.83 mmol) of 4-(3-Methanesulfonyloxy-prop-1-ynyl)-piperidine-1-carboxylic acid 4-chloro-phenyl ester and 0.79 ml (8.3mmol) of N-methylallylamine in 7 ml of methanol was stirred over night at RT. Then an aqueous solution of 1N NaOH was added and extracted with ether (3×). The organic phase was dried with Na2SO4, filtered and evaporated. The residue was purified by flash column chromatography on silica gel (CH2Cl2/MeOH 19:1 to 9:1) to yield 201 mg (70%) of pure 4-[3-(Allyl-methyl-amino)-prop 1 ynyl]-piperidine-1-carboxylic acid 4-chloro-phenyl ester, MS: 347 (MH+, 1Cl).

Provenance & Evidence