HCID 22279369, compound → HCID 22279510, compound

Participants

Reaction Steps

A suspension of 83 mg (0.198 mmol) of Methyl-propyl-{4-[1-(4-trifluoromethyl-benzenesulfonyl)-piperidin-4-yl]-but-3-ynyl}-amine in 4 ml EtOH and 8 mg of PtO2.H2O was hydrogenated (1 atm) for 7 h. The reaction was filtered and evaporated. Flash column chromatography on silica gel (CH2Cl2/MeOH 19:1 to 9:1) gave 78 mg (93%) of Methyl-propyl-{4-[1-(4-trifluoromethyl-benzenesulfonyl)-piperidin-4-yl]-butyl}-amine, mp: 73.0-74.8° C., MS: 421 (MH+).

Provenance & Evidence