Benzyl Bromide → HCID 69797921, compound

Participants

Reaction Steps

(3RS, 4RS) 4-Aminomethyl-3-phenyl-dihydrofuran-2-one (2.15 g, 0.011 mol) was added to potassium carbonate (15.5 g), benzyl bromide (6.69 ml) and dimethylformamide (10 ml) and stirred for 3 hours at 50° C. dimethylformamide was removed in vacuo and the reaction was dispersed between ethyl acetate (40 ml) and water (60 ml), the aqueous phase was washed with ethyl acetate (2×30 ml) and the organic layers were combined and washed with brine solution (100 ml) and dried over MgSO4. The solvent was removed in vacuo and purified by flash column chromatography on silica gel and eluting in increasing concentrations of ethyl aceate in hexane (5-50%) to give the title compound (1.15 g, 46%).

Provenance & Evidence