HCID 69338143, compound → (2R)-t-Butoxycarbonylamino-1-n-hexanoyloxy-2-methyl-4-(thiophen-2-yl)butane

Participants

Reaction Steps

(2R)-t-Butoxycarbonylamino-1-n-hexanoyloxy-2-methyl-4-(thiophen-2-yl)-3-butene (27.6 g, 72.4 mmol) obtained in Example 66(c) was dissolved in ethanol (450 ml), and 10% palladium-charcoal (14.0 g) was added thereto followed by stirring for 4 days at room temperature under a hydrogen atmosphere. After the palladium-charcoal in the reaction solution was filtered out through Celite, the filtrate was evaporated to dryness under reduced pressure. The residue was purified by chromatography on a silica gel column (elution solvent; hexane:ethyl acetate=20:1-10:1) to give the title compound (22.1 g, 80% yield) as a colorless oil.

Provenance & Evidence