HCID 69338406, compound → HCID 20721235, compound

Participants

Reaction Steps

(2R)-t-Butoxycarbonylamino-1-n-hexanoyloxy-2-methyl-4-(benzo[b]thiophen-6-yl)-3-butene (28.0 g, 64.9 mmol) obtained in Example 68(a) was dissolved in methanol (700 ml), and 10% palladium-charcoal (14.0 g) was added thereto followed by stirring for 6 days at room temperature under a hydrogen atmosphere. After the palladium-charcoal in the reaction solution was filtered out through Celite, the filtrate was evaporated under reduced pressure. The residue was purified by chromatography on a silica gel column (elution solvent; hexane:ethyl acetate=15:1-10:1) to give the title compound (24.30 g, 87% yield) as a colorless oil.

Provenance & Evidence